1. Gjorgjieva M, Calderaro J, Monteillet L, Silva M, Raffin M, Brevet M, Romestaing C, Roussel D, Zucman-Rossi J, Mithieux G, Rajas F. Dietary exacerbation of metabolic stress leads to accelerated hepatic carcinogenesis in glycogen storage disease type Ia. J Hepatol. 2018 Sep 4. pii: S0168-8278(18)32271-2. doi: 10.1016/j.jhep.2018.07.017.

  2. Monteillet L, Gjorgjieva M, Silva M, Verzieux V, Imikirene L, Duchampt A, Guillou H, Mithieux G, Rajas F. Intracellular lipids are an independent cause of liver injury and chronic kidney disease in non alcoholic fatty liver disease-like context. Mol Metab. 2018 Oct;16:100-115

  3. Kaneko K, Soty M, Zitoun C, Duchampt A, Silva M, Philippe E, Gautier-Stein A, Rajas F, Mithieux G. The role of kidney in the inter-organ coordination of endogenous glucose production during fasting. Mol Metab. 2018 Oct;16:203-212.

  4. Gjorgjieva M, Monteillet L, Calderaro J, Mithieux G, Rajas F. Polycystic kidney features of the renal pathology in glycogen storage disease type I: possible evolution to renal neoplasia. J Inherit Metab Dis. 2018 Jun 4. doi: 10.1007/s10545-018-0207-y.

  5. Mithieux G. Gut nutrient sensing and microbiota function in the control of energy homeostasis. Curr Opin Clin Nutr Metab Care. 2018 Jul;21(4):273-276.

  6. Pursell N, Gierut J, Zhou W, Dills M, Diwanji R, Gjorgjieva M, Saxena U, Yang JS, Shah A, Venkat N, Storr R, Kim B, Wang W, Abrams M, Raffin M, Mithieux G, Rajas F, Dudek H, Brown BD, Lai C. Inhibition of Glycogen Synthase II with RNAi Prevents Liver Injury in Mouse Models of Glycogen Storage Diseases. Mol Ther. 2018 Jul 5;26(7):1771-1782.

  7. Mithieux G. Does Akkermansia muciniphila play a role in type 1 diabetes? Gut. 2018 Aug;67(8):1373-1374.

  8. Vidal P, Pagliarani S, Colella P, Costa Verdera H, Jauze L, Gjorgjieva M, Puzzo F, Marmier S, Collaud F, Simon Sola M, Charles S, Lucchiari S, van Wittenberghe L, Vignaud A, Gjata B, Richard I, Laforet P, Malfatti E, Mithieux G, Rajas F, Comi GP, Ronzitti G, Mingozzi F. Rescue of GSDIII Phenotype with Gene Transfer Requires Liver- and Muscle-Targeted GDE Expression. Mol Ther. 2018 Mar 7;26(3):890-901.

  9. de Vadder F, Mithieux G. Gut-brain signaling in energy homeostasis: the unexpected role of microbiota-derived succinate. J Endocrinol. 2018 Feb;236(2):R105-R108.

  10. Mithieux G. Gut microbiota and host metabolism: what relationship?  Neuroendocrinology. 2018;106(4):352-356.


  1. Hijmans BS, Boss A, van Dijk TH, Soty M, Wolters H, Mutel E, Groen AK, Derks TGJ, Mithieux G, Heerschap A, Reijngoud DJ, Rajas F, Oosterveer MH. Hepatocytes contribute to residual glucose production in a mouse model for glycogen storage disease type Ia. Hepatology. 2017 Jul 20. doi: 10.1002/hep.29389.

  2. Soty M, Gautier-Stein A, Rajas F, Mithieux G. Gut-Brain Glucose Signaling in Energy Homeostasis. Cell Metab. 2017 Jun 6;25(6):1231-1242.

  3. Weis S, Carlos AR, Moita MR, Singh S, Blankenhaus B, Cardoso S, Larsen R, Rebelo S, Schäuble S, Del Barrio L, Mithieux G, Rajas F, Lindig S, Bauer M, Soares MP. Metabolic Adaptation Establishes Disease Tolerance to Sepsis. Cell. 2017 Jun 15;169(7):1263-127.

  4. Barataud A, Goncalves D, Vinera J, Zitoun C, Duchampt A, Gautier-Stein A, Mithieux G. Absence of Role of Dietary Protein Sensing in the Metabolic Benefits of Duodenal-Jejunal Bypass in the Mouse. Sci Rep. 2017 Mar 23;7:44856.

  5. Velmurugan G, Ramprasath T, Swaminathan K, Mithieux G, Rajendhran J, Dhivakar M, Parthasarathy A, Babu DD, Thumburaj LJ, Freddy AJ, Dinakaran V, Puhari SS, Rekha B, Christy YJ, Anusha S, Divya G, Suganya K, Meganathan B, Kalyanaraman N, Vasudevan V, Kamaraj R, Karthik M, Jeyakumar B, Abhishek A, Paul E, Pushpanathan M, Rajmohan RK, Velayutham K, Lyon AR, Ramasamy S. Gut microbial degradation of organophosphate insecticides-induces glucose intolerance via gluconeogenesis. Genome Biol. 2017 Jan 24;18(1):8.



  1. Casteras S, Abdul-Wahed A, Soty M, Vulin F, Guillou H, Campana M, Le Stunff H, Pirola L, Rajas F, Mithieux G, Gautier-Stein A. The suppression of hepatic glucose production improves metabolism and insulin sensitivity in subcutaneous adipose tissue in mice. Diabetologia. 2016, 59(12):2645-2653.

  2. Montagner A, Korecka A, Polizzi A, Lippi Y, Blum Y, Canlet C, Tremblay-Franco M, Gautier-Stein A, Burcelin R, Yen YC, Je HS, Al-Asmakh M, Mithieux G, Arulampalam V, Lagarrigue S, Guillou H, Pettersson S, Wahli W. Hepatic circadian clock oscillators and nuclear receptors integrate microbiome-derived signals. Sci Rep. 2016, 6:20127.

  3. Lee YS, De Vadder F, Tremaroli V, Wichmann A, Mithieux G, Bäckhed F. Insulin-like peptide 5 is a microbially regulated peptide that promotes hepatic glucose production. Mol Metab. 2016, 5(4):263-70.

  4. Soty M, Chilloux J, Delalande F, Zitoun C, Bertile F, Mithieux G, Gautier-Stein A. Post-Translational Regulation of the Glucose-6-Phosphatase Complex by Cyclic Adenosine Monophosphate Is a Crucial Determinant of Endogenous Glucose Production and Is Controlled by the Glucose-6-Phosphate Transporter. J Proteome Res. 2016, 15(4):1342-9.

  5. Montagner A, Polizzi A, Fouché E, Ducheix S, Lippi Y, Lasserre F, Barquissau V, Régnier M, Lukowicz C, Benhamed F, Iroz A, Bertrand-Michel J, Al Saati T, Cano P, Mselli-Lakhal L, Mithieux G, Rajas F, Lagarrigue S, Pineau T, Loiseau N, Postic C, Langin D, Wahli W, Guillou H. Liver PPARα is crucial for whole-body fatty acid homeostasis and is protective against NAFLD. Gut. 2016, 65(7):1202-14.

  6. De Vadder F., Kovatcheva-Datchary P., Zitoun C., Duchampt A., Bäckhed F., and Mithieux G. Microbiota-produced succinate improves glucose homeostasis via intestinal gluconeogenesis. Cell Metab. 2016 24(1):151-7.

  7. Gjorgjieva M., Raffin M., Duchampt A., Perry A., Stefanutti A., Brevet M., Tortereau A., Dubourg L., Hubert-Buron A., MabilleM., Pelissou C., Lassalle L., Labrune P., Mithieux G. and Rajas F. Progressive development of renal cysts in glycogen storage disease type I. Hum Mol Gen, 2016 Sep 1;25(17):3784-3797.




  1. De Vadder F, Plessier F, Gautier-Stein A, Mithieux G. Vasoactive intestinal peptide is a local mediator in a gut-brain neural axis activating intestinal gluconeogenesis. Neurogastroenterol Motil. 2015, 27(3):443-8.

  2. Goncalves D, Barataud A, De Vadder F, Vinera J, Zitoun C, Duchampt A, Mithieux G. Bile Routing Modification Reproduces Key Features of Gastric Bypass in Rat. Ann Surg. 2015, 262(6):1006-15.

  3. Clar J, Mutel E, Gri B, Creneguy A, Stefanutti A, Gaillard S, Ferry N, Beuf O, Mithieux G, Nguyen TH, Rajas F. Hepatic lentiviral gene transfer prevents the long-term onset of hepatic tumours of glycogen storage disease type 1a in mice. Hum Mol Genet. 2015, 15;24(8):2287-96.

  4. Soty M., Penhoat A., Amigo-Correig M., Vinera J., Sardella A., Vullin-Bouilloux F., Zitoun C., Houberdon I., Mithieux G. A gut-brain neural circuit controlled by intestinal gluconeogenesis is crucial in metabolic health. Mol Metab. 2015, 4:106-117



  1. Mithieux G. Nutrient Control of Energy Homeostasis Via Gut-Brain Neural Circuits. Neuroendocrinology. 2014, 100(2-3):89-94.

  2. Mithieux G. Crosstalk between gastrointestinal neurons and the brain in the control of food intake. Best Pract Res Clin Endocrinol Metab. 2014, 28(5):739-44.

  3. Mithieux G. Metabolic effects of portal vein sensing. Diabetes Obes Metab. 2014, Suppl 1:56-60.

  4. Rajas F., Clar J., Gautier-Stein A., Mithieux G. Lessons from new mouse models of glycogen storage disease type 1a in relation to the time course and organ specificity if the disease. J Inherit Metab Dis., 2014, 38(3):521-7

  5. Abdul-Wahed, A., A. Gautier-Stein, S. Casteras, M. Soty, D. Roussel, C. Romestaing, H. Guillou, J.A. Tourette, N. Pleche, C. Zitoun, B. Gri, A. Sardella, F. Rajas, and G. Mithieux, A link between hepatic glucose production and peripheral energy metabolism via hepatokines. Mol Metab, 2014. 3(5):531-43.

  6. Binder, E., F.J. Bermudez-Silva, M. Elie, T. Leste-Lasserre, I. Belluomo, S. Clark, A. Duchampt, G. Mithieux, and D. Cota, Leucine supplementation modulates fuel substrates utilization and glucose metabolism in previously obese mice. Obesity (Silver Spring), 2014. 22(3): p. 713-20.

  7. Clar, J., B. Gri, J. Calderaro, M.C. Birling, Y. Herault, G.P. Smit, G. Mithieux, and F. Rajas, Targeted deletion of kidney glucose-6 phosphatase leads to nephropathy. Kidney Int, 2014. 86(4):747-56.

  8. De Vadder, F., P. Kovatcheva-Datchary, D. Goncalves, J. Vinera, C. Zitoun, A. Duchampt, F. Backhed, and G. Mithieux, Microbiota-generated metabolites promote metabolic benefits via gut-brain neural circuits. Cell, 2014. 156(1-2): p. 84-96.

  9. Mithieux, G., Nutropioids regulate gut-brain circuitry controlling food intake. Front Horm Res, 2014. 42:155-62.

  10. Mithieux, G. and A. Gautier-Stein, Intestinal glucose metabolism revisited. Diabetes Res Clin Pract, 2014. 105(3):295-301.

  11. Penhoat, A., L. Fayard, A. Stefanutti, G. Mithieux, and F. Rajas, Intestinal gluconeogenesis is crucial to maintain a physiological fasting glycemia in the absence of hepatic glucose production in mice. Metabolism, 2014. 63(1):104-11.



  1. Binder, E., F.J. Bermudez-Silva, C. Andre, M. Elie, S.Y. Romero-Zerbo, T. Leste-Lasserre, I. Belluomo, A. Duchampt, S. Clark, A. Aubert, M. Mezzullo, F. Fanelli, U. Pagotto, S. Laye, G. Mithieux, and D. Cota, Leucine supplementation protects from insulin resistance by regulating adiposity levels. PLoS One, 2013. 8(9): p. e74705.

  2. De Vadder, F., A. Gautier-Stein, and G. Mithieux, [Opioid receptors associated with portal vein regulate a gut-brain neural circuitry limiting food intake]. Med Sci (Paris), 2013. 29(1): 31-3.

  3. De Vadder, F., A. Gautier-Stein, and G. Mithieux, Satiety and the role of mu-opioid receptors in the portal vein. Curr Opin Pharmacol, 2013. 13(6): 959-63.

  4. Delaere, F., H. Akaoka, F. De Vadder, A. Duchampt, and G. Mithieux, Portal glucose influences the sensory, cortical and reward systems in rats. Eur J Neurosci, 2013. 38(10):3476-86.

  5. Delaere, F., A. Duchampt, L. Mounien, P. Seyer, C. Duraffourd, C. Zitoun, B. Thorens, and G. Mithieux, The role of sodium-coupled glucose co-transporter 3 in the satiety effect of portal glucose sensing. Mol Metab, 2013. 2(1):47-53.

  6. Gautier-Stein, A. and G. Mithieux, A role for PYY3-36 in GLP1-induced insulin secretion. Mol Metab, 2013. 2(3): 123-5.

  7. Huber, A.L., J. Lebeau, P. Guillaumot, V. Petrilli, M. Malek, J. Chilloux, F. Fauvet, L. Payen, A. Kfoury, T. Renno, E. Chevet, and S.N. Manie, p58(IPK)-mediated attenuation of the proapoptotic PERK-CHOP pathway allows malignant progression upon low glucose. Mol Cell, 2013. 49(6): 1049-59.

  8. Mithieux, G., Nutrient control of hunger by extrinsic gastrointestinal neurons. Trends Endocrinol Metab, 2013. 24(8): 378-84.

  9. Mithieux, G., Influence of diabetes surgery on a gut-brain-liver axis regulating food intake and internal glucose production. Nutr Hosp, 2013. 28 Suppl 2: 109-14.

  10. Rajas, F., P. Labrune, and G. Mithieux, Glycogen storage disease type 1 and diabetes: learning by comparing and contrasting the two disorders. Diabetes Metab, 2013. 39(5): 377-87.

  11. Ramamonjisoa, N., H. Ratiney, E. Mutel, H. Guillou, G. Mithieux, F. Pilleul, F. Rajas, O. Beuf, and S. Cavassila, In vivo hepatic lipid quantification using MRS at 7 Tesla in a mouse model of glycogen storage disease type 1a. J Lipid Res, 2013. 54(7): 2010-22.

  12. Wei, K., S.M. Piecewicz, L.M. McGinnis, C.M. Taniguchi, S.J. Wiegand, K. Anderson, C.W. Chan, K.X. Mulligan, D. Kuo, J. Yuan, M. Vallon, L.C. Morton, E. Lefai, M.C. Simon, J.J. Maher, G. Mithieux, F. Rajas, J.P. Annes, O.P. McGuinness, G. Thurston, A.J. Giaccia, and C.J. Kuo, A liver Hif-2alpha-Irs2 pathway sensitizes hepatic insulin signaling and is modulated by Vegf inhibition. Nat Med, 2013. 19(10): 1331-7.



  1. Duraffourd, C., F. De Vadder, D. Goncalves, F. Delaere, A. Penhoat, B. Brusset, F. Rajas, D. Chassard, A. Duchampt, A. Stefanutti, A. Gautier-Stein, and G. Mithieux, Mu-opioid receptors and dietary protein stimulate a gut-brain neural circuitry limiting food intake. Cell, 2012. 150(2): 377-88.

  2. Gautier-Stein, A., M. Soty, J. Chilloux, C. Zitoun, F. Rajas, and G. Mithieux, Glucotoxicity induces glucose-6-phosphatase catalytic unit expression by acting on the interaction of HIF-1alpha with CREB-binding protein. Diabetes, 2012. 61(10): 2451-60.

  3. Mithieux, G., A synergy between incretin effect and intestinal gluconeogenesis accounting for the rapid metabolic benefits of gastric bypass surgery. Curr Diab Rep, 2012. 12(2): 167-71.

  4. Mithieux, G., The role of gut glucose metabolism in the control of food intake. Curr Nut Food Science, 2012. 8: 45-48.

  5. Mithieux, G., Comment about intestinal gluconeogenesis after gastric bypass in human in relation with the paper by Hayes et al., Obes. Surg. 2011. Obes Surg, 2012. 22(12):1920-2; author reply 1923-4.

  6. Naville, D., A. Duchampt, M. Vigier, D. Oursel, R. Lessire, H. Poirier, I. Niot, M. Begeot, P. Besnard, and G. Mithieux, Link between intestinal CD36 ligand binding and satiety induced by a high protein diet in mice. PLoS One, 2012. 7(1): p. e30686.

  7. Soty, M., J. Chilloux, S. Casteras, A. Grichine, G. Mithieux, and A. Gautier-Stein, New insights into the organisation and intracellular localisation of the two subunits of glucose-6-phosphatase. Biochimie, 2012. 94(3): 695-703.



  1. Mutel, E., A. Abdul-Wahed, N. Ramamonjisoa, A. Stefanutti, I. Houberdon, S. Cavassila, F. Pilleul, O. Beuf, A. Gautier-Stein, A. Penhoat, G. Mithieux, and F. Rajas, Targeted deletion of liver glucose-6 phosphatase mimics glycogen storage disease type 1a including development of multiple adenomas. J Hepatol, 2011. 54: 529-537.

  2. Mutel, E., A. Gautier-Stein, A. Abdul-Wahed, M. Amigo-Correig, C. Zitoun, A. Stefanutti, I. Houberdon, J.A. Tourette, G. Mithieux, and F. Rajas, Control of blood glucose in the absence of hepatic glucose production during prolonged fasting in mice: induction of renal and intestinal gluconeogenesis by glucagon. Diabetes, 2011. 60(12): 3121-31.

  3. Penhoat, A., E. Mutel, M.A. Correig, B. Pillot, A. Stefanutti, F. Rajas, and G. Mithieux, Protein-induced satiety is abolished in the absence of intestinal gluconeogenesis. Physiol Behav, 2011. 105(1):89-93

  4. Pillot, B., C. Duraffourd, M. Begeot, A. Joly, S. Luquet, I. Houberdon, D. Naville, M. Vigier, A. Gautier-Stein, C. Magnan, and G. Mithieux, Role of hypothalamic melanocortin system in adaptation of food intake to food protein increase in mice. PLoS One, 2011. 6(4): p. e19107.